Description
Flogodren capsule è a food supplement with an effective anti-inflammatory and anti-edema action based on bromelain from pineapple, aescin from horse chestnut and boswellia serrata resin. Bromelain è an enzyme with activity; proteolytic extracted from the pineapple stem. It is absorbed in the intestine and has a strong anti-inflammatory and anti-edema action capable of reducing tissue edema and for this reason it is used to decongest soft tissues. (Post surgery, trauma, inflammatory joint diseases, bruises and sprains).
A mixture of saponins called escin is extracted from the seeds, bark and leaves of horse chestnut, which possesses known properties; medicines. This phytocomplex recognizes several active molecules with proven anti-inflammatory action such as elucoside, and antioxidant such as flavonoids and procyanidins. Aescin increases the resistance of the capillaries and reduces their permeability. It therefore exerts an anti-edema action, supported by the capacity; to intervene on the local electrolyte exchange, favoring the removal of accumulated interstitial liquids. This capillarotropic and drainage action, together with properties; anti-inflammatory and mild activity; antithrombotic, they make horse chestnut extracts standardized in escin indicated in the presence of peripheral venous insufficiency disorders (swelling, heaviness, pain, itching, etc.), varicose veins and post-phlebitic syndromes, hemorrhoids, cellulite, fragility à capillary and edema.
Boswellia serrata, a plant rich in boswellic acid, is; able to inhibit the 5-lipoxygenase enzyme responsible for the action of chronic inflammatory processes, to inhibit elastases, enzymes that attack the elastic part of the tissues where it is an ongoing inflammatory process and to prevent the infiltration of polymorphonuclear cells that contribute to the destruction of connective tissue. It is used in the treatment of chronic inflammatory diseases with allergic immunological pathogenesis. Particularly indicated in inflammations of the soft tissues, muscles and joints but also of the gastrointestinal tract (Rectocolitis, Chron's disease) and respiratory tract (anti-asthmatic activity).

Gluten free (less than 20 ppm).

Mode à for use
It is recommended to take 1 capsule a day, unless otherwise indicated by the doctor, between meals.

Warnings
No known effects collateral related to the use of the product, avoid in case of ascertained hypersensitivity; to one or more; components of the product. Keep out of the reach of children under 3 years old. Do not exceed recommended daily doses. Supplements are not intended as a substitute for a varied, balanced diet and a healthy lifestyle.

Storage
Store in a cool and dry place, away from light and away from heat sources. Use by the date shown on the package. The expiry date refers to the product in intact and correctly stored packaging.
Validity à unopened: 36 months.

Format
Box of 20 capsules of 550 mg.

Bibliography
< b> 1. Miller J and Opher A: The increased proteolytic activity of human blood serum after oral administration of Bromelain. Exp Med Surg 22, 277-280, 1964.
2. Izaka K, Yamada M, KawanoT, and SuyamaT: Gastrointestinal absorption and anti-inflammatory euect of Bromelain. Jpn J Pharmacol 22, 519-534, 1972.
3. Ganzera M, Khan IA. A reversed phase high performance liquid chromatography method for the analysis of boswellic acids in Boswellia serrata. Planta Med, 67 (8): 778-80, 2001.
4. Singh GB, Atal CK. Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new non-steroidal anti-inflammatory agent. Agents Actions, 18: 407-12, 1986.
5. Indian Physiol Pharmacol. 201 Oct-Dec; 56 (4): 367-74. Anti-inflammatory euect of the serratiopeptidase- rationale or fashionable: a study in rat paw oedema model induced by the carrageenan.
6. Minerva Urol Nefrol. 2005 Mar; 57 (1): 53-9. Treatment with non-steroidal anti-inflammatory drugs in patients with amicrobial chronic prostato-vesiculitis: transrectal ultrasound and seminal findings].
7. Boll Chim Farm. 1985 Aug; 124 (8): 71S-75S. Comparison between imidazole-2-hydroxybenzoate and serratio-peptidase in the treatment of phlogistic diseases of the respiratory tract].